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CAS 41100-52-1 Longan Powder Memantine HCl Powder For Vascular Dementia

CAS 41100-52-1 Longan Powder Memantine HCl Powder For Vascular Dementia

CAS 41100-52-1 Longan Powder Memantine HCl Powder For Vascular Dementia
CAS 41100-52-1 Longan Powder Memantine HCl Powder For Vascular Dementia
CAS 41100-52-1 Longan Powder Memantine HCl Powder For Vascular Dementia
Product Details:
Place of Origin: China
Brand Name: LiHui
Certification: Hplc ISO9001
Model Number: 41100 -52-1
Payment & Shipping Terms:
Minimum Order Quantity: 10kg
Price: Negotiated
Packaging Details: Foil Bag
Delivery Time: 3-7days after received payment
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 5000Kg Per Month
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Detailed Product Description
CAS: 41100 -52-1 Color Or Appearance: A Tablet Or Capsule
Packing Specification: Aluminum Foil Bag Or Aluminum Tin 25 Kg/barrel Execution Standard: USP42
Product Purity: 99% The Product Level: Pharmaceutical Grade
Molecular Formula: C12H21N Product Use: Longan Powder
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41100-52-1 Longan Powder


41100-52-1 Memantine HCl Powder


Longan Powder Memantine HCl


CAS 41100 52 1 Nootropic Powder Memantine HCl Powder For Anti Alzheimer Drug



Product Name: Memantine
Synonyms: AKOS BB-9600;MEMANTINE;AURORA KA-7643;TIMTEC-BB SBB002574;3,5-dimethyladamantan-1-amine HCl;1-Amino-3,5-dimethyladamantane;3,5-Dimethyl-1-aminoadamantane;3,5-DIMETHYL-1-AMINOADAMANTANE(MEMANTINE)
CAS: 19982-08-2
MF: C12H21N
MW: 179.3
Product Name: Memantine HCl
CAS: 41100-52-1
MF: C12H22ClN
MW: 215.76
EINECS: 255-219-6


Hemical Properties Crystalline Solid
Uses Used as an antiparkinsonian and antispasmodic
Uses Antiparkinsonian;Dopaminergic agonist
Uses Anti Alzheimer's

CAS 41100 52 1 Nootropic Powder Memantine HCl Powder For Anti Alzheimer Drug 0



Melting point:292 °C

storage temp. -20°C Freezer

form Fine Powder

color White

Merck 5806



Overview of memantine hydrochloride is dementia drugs developed by the German company Merz, is a new type of low, moderate affinity, voltage dependent and non competitive N methyl D aspartate (NMDA) receptor antagonist can noncompetitive NMDA receptor blockade induced by glutamate receptor NMDA, reduce the excessive excitement, prevent cell apoptosis, improve memory, is a new generation of drugs to improve cognitive function.

In February 2002, the European Commission (CPMP) approved the drug patent for moderate to severe Alzheimer's disease treatment, in August of the same year in the German market, in October 17, 2003 by the U.S. Food and Drug Administration (FDA) approved for the treatment of moderate to severe Alzheimer's disease patients. Further studies show that memantine hydrochloride is effective for mild to moderate Alzheimer's disease.

Memantine HCl is the HCl form of Memantine. Memantine is a well- known neuroprotective drug used for the treatment of Alzheimer's disease. It is believed to be the first neuroprotective drug that has achieve clinical approval by US FDA as well as European. The development of Alzheimer's disease involves the misfolded mutant proteins such as β-amyloid peptide (Aβ, particularly Aβ1−42). These misfolded mutant protein can increase the NMDA response and further cause severe excitotoxicity. Memantine suppresses this process through acting as the antagonist of the N-methyl-d- aspartate-sensitive glutamate receptor (NMDARs). Memantine is also under investigation as a potential treatment for other kind of neurodegenerative disorders such as HIV-associated dementia, neuropathic pain, glaucoma, depression, Huntington's disease, ALS and movement disorders, among other.

what is Alzheimer's disease?

Alzheimer's disease (Alzheimer, disease, AD), also known as Alzheimer's disease, is one of the common diseases of the elderly, mainly for the loss of memory and ability to identify barriers, is a progressive neurological degenerative disease. At present, cholinesterase inhibitors (donepezil, galantamine, Kabbala ting) and memantine hydrochloride is approved for the treatment of Blzheimer's disease.

Characters of memantine hydrochloride is white crystal or powder. Molecular weight: 215.81.
Pharmacokinetics of oral administration of memantine hydrochloride has good absorption, and no food, treatment dose range, the linear dynamic feature of medicine, age and gender does not affect its pharmacokinetics. Oral administration of 3 ~ 7h peak blood concentration of t1/2 is 60 ~ 80h, the average volume of distribution of 9 ~ 11L / kg -1, the 45% rate of plasma protein binding, 57% ~ 82% to the rest of the prototype, metabolite of N -3, 5- two - methyl glucuronide, 6- hydroxy memantine and 1- nitroso - deamination dollars just by the form of urine excretion. Metabolites have a certain NMDA receptor antagonist activity. Renal clearance was affected by urine pH, urine pH value was 8, renal clearance decreased by 80%.

CAS 41100 52 1 Nootropic Powder Memantine HCl Powder For Anti Alzheimer Drug 1


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