Indications and Use Stendra is an inhibitor of phosphodiesterase 5(PDE5)Avanafil tablets
[Generic name] vanafil (vanafil)
【Registration classification】Chemical drugs 3+3 category
[Dosage Forms and Specifications] Tablets, 50mg, 100mg, 200mg
[Usage and Dosage] For most patients, the starting dose is 100mg, which should be taken orally about 30 minutes before sex, and Stendra should be taken no more than once a day as needed. Depending on the efficacy and tolerability, the dose can be increased to 200mg or reduced to 50mg, the doctor should prescribe the lowest dose that can achieve the effect. The minimum recommended frequency of dosing is 1 day each time.
【Indications】Used to treat erectile dysfunction.
[Foreign listing situation] This product was developed by Tanabe Pharmaceutical Co., Ltd. and VIVUS Co., Ltd., and was approved for listing in the United States on April 27, 2012.
[Patent Status] The compound patent was rejected, and the formulation patent (02805070.3) expired in February 2022.
[Pharmacological action] Avanafil is a phosphodiesterase-5 inhibitor, which can increase the blood flow of the penis. Like other similar drugs (such as sildenafil, commonly known as "Viagra"), it cannot be used for male patients who also take nitrates to treat chest pain, otherwise it may cause a sharp drop in blood pressure.
[Clinical trials] In clinical trials, 77% of men with ED were able to get an erection after taking avanafil (Stendra), compared with 54% of men taking an ineffective placebo. Among patients with diabetes-related ED, 63% of men were able to get an erection after taking the drug, compared with 42% of men taking a placebo. Stendra enabled 57% of men with ED to have sexual intercourse (27% of men who took a placebo), and 40% of men with diabetes-related ED (20% of men who took a placebo).
[Project advantage] Compared with other anti-ED drugs, the biggest advantage of avanafil is that it takes effect quickly. It is stated that patients should take it 30 minutes before sex. But in research, the drug has been shown to work in as little as 15 minutes, faster than the 30-60 minutes reported by other drugs. Eating can affect the pharmacokinetics of sildenafil and vardenafil, but not avanafil.
The rapid onset of avanafil allows ED patients to enjoy sex at any time without having to take medications in advance, and there are no obvious side effects! Avanafil is a strong competitor of Sildenafil (Viagra), a very promising species, and it is worthy of project development!