High Purity Antibiotic API 62-44-2 Phenacetin Acetophenetidin For Antipyretic

Descriptions

Phenacetin is a pain-relieving and fever-reducing drug, widely used from its introduction in 1887 until banned in the US by the FDA in 1983. Its use has declined because of its adverse effects, which include increased risk of certain cancers and kidney damage.

It is metabolized into paracetamol, which replaced it in some over-the-counter medications following the ban on phenacetin.

Application

Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an "A.P.C." or aspirin-phenacetin-caffeine compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincent's APC in Australia. However the U.S.

Food and Drug Administration ordered the withdrawal of drugs containing phenacetin in November 1983, owing to its carcinogenic and kidney-damaging properties (Federal Register of October 5, 1983 (48 FR 45466)

Synonyms

• Acetophenetidin
• Acetophenetidine
• Acetophenetin
• Acetphenetidin
• Fenacetina
• Phenacetin

Phenacetin effect
1.Phenacetin may be used as a treatment for rheumatoid arthritis.
2.Phenacetin used in veterinary medicine was shown to cause tumors in rats during experimental laboratory studies.
3.Acetaminophen is commonly used to treat arthritis.
4.phenacetin was commonly used as a fever reducer.

Phenacetin Usage
Usage 1 Analgesic, antipyretic. Component of APC tablets, analgesic mixture also containing aspirin and caffeine. Phenacetin is reasonably anticipated to be a human carcinogen; analgesic mixtures containing Phenacetin are listed as known human carcinogens.
Usage 2 glycosylation inhibitor
Usage 3 Used for organic synthesis of raw materials and drug intermediates from acetaminophen ether.
Usage 4 Antipyretic analgesics for the treatment of fever, headache, neuralgia.
Usage 5 Active pharmaceutical ingredient for Scientific Research.

Phenacetin function:

The antipyretic effect is stronger than the analgesic effect. The effect of intensity is slow and long lasting, as aspirin, with low toxicity. research shows:

This product and its metabolites have antipyretic effects on acetaminophen. Because enzyme inhibitors do not convert phenylacetic acetate into paracetamol, there is still a significant antipyretic effect, so the antipyretic effect of the post-production line does not translate into paracetamol.

Mild phenacetin acetate analgesia usually lasts 3 to 4 hours; and synergistic, co-administration can improve the analgesic effect.

The main clinical application of antipyretic analgesics for small animals. This product is also a component of the APC Tablet PC.

Phenacetin COA:

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