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|CAS:||846589-98-8||Color Or Appearance:||White Crystalline Powder|
|Product Use:||To Treat Obesity.||Packing Specification:||Aluminum Foil Bag Or Aluminum Tin 25 Kg/barrel|
|Execution Standard:||USP42||Product Purity:||99%|
|The Product Level:||Pharmaceutical Grade||Molecular Formula:||C11H14ClN·ClH|
846589-98-8 Lorcaserin Hydrochloride,
846589-98-8 Steroids Fat Loss,
Lorcaserin Hydrochloride Steroids Fat Loss
Pharmaceutical Grade Fat Loss Steroids Lorcaserin Hydrochloride CAS 846589-98-8
Synonyms: (R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE;LORCASERIN HCL;Lorcaserin hydrochloride;(R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride;
Molecular formula: C11H14ClN·ClH
Molecular weight: 232.1525
CAS: 846589-98-8; 1431697-94-7
Flash point: 307.321°C
Appearance White Crystalline Powder
Adjunct to caloric restriction and increased physical activity in the chronic management of obesity.
Used in patients who are obese (pretreatment body mass index [BMI] ≥30 kg/m2); also used in overweight patients with pretreatment BMI ≥27 kg/m2 in the presence of a weight-related risk factor or disease (e.g., hypertension, type 2 diabetes mellitus, dyslipidemia).
Indicated only for monotherapy; safety and efficacy in combination with other weight loss products (prescription drugs [e.g., phentermine], OTC drugs, herbal preparations) not established.
Long-term effects on cardiovascular morbidity and mortality associated with obesity not established; safety and efficacy beyond 2 years of use not established.
Lorcaserin VS Orlistat:
Lorcaserin is a selective 5-HT2C receptor agonist,and in vitro testing of the drug showed reasonable selectivity for 5-HT2C over other related targets. 5-HT2C receptors are located almost exclusively in the brain. The activation of 5-HT2C receptors in the hypothalamus is supposed to activate proopiomelanocortin (POMC) production and consequently promote weight loss through satiety.The safety and effectiveness was tested in the 3 clinical trials which nearly 8000 overweight or obese participants were involved.
Orlistat works by inhibiting gastric and pancreatic lipases, the enzymes that break down triglycerides in the intestine. When lipase activity is blocked, triglycerides from the diet are not hydrolyzed into absorbable free fatty acids, and instead are excreted unchanged. Only trace amounts of orlistat are absorbed systemically; the primary effect is local lipase inhibition within the GI tract after an oral dose. The primary route of elimination is through the feces. But for a part of stubborn obesity who get good appetite, the treatment effect is not ideal.
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|Product Name:Lorcaserin||Batch No:140516|
|Analysis Date:2014.05.17||Retest Date:2017.05.16|
Ethyl acetate 0.5%
Lorcaserin powder is a selective 5-HT2C receptor agonist, and in vitro testing of the drug showed reasonable selectivity for 5-HT2C over other related targets. 5-HT2C receptors are located almost exclusively in the brain, and can be found in the choroid plexus, cortex, hippocampus, cerebellum, amygdala, thalamus, andhypothalamus. The activation of 5-HT2C receptors in the hypothalamus is supposed to activate proopiomelanocortin(POMC) production and consequently promote weight loss through satiety. This hypothesis is supported by clinical trials and other studies. While Lorcaserin hydrochloride powder is generally thought that 5-HT2C receptors help to regulate appetite as well as mood, and endocrine secretion, the exact mechanism of appetite regulation is not yet known. Lorcaserin has shown 100x selectivity for 5-HT2C versus the closely related 5-HT2B receptor.
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