|Place of Origin:||India|
|Minimum Order Quantity:||100g|
|Packaging Details:||Foil Bag|
|Delivery Time:||3-7days after received payment|
|Payment Terms:||T/T, Western Union, MoneyGram|
|Supply Ability:||5000Kg Per Month|
955365-80-7 Sarms Bodybuilding Supplements,
Sarms Bodybuilding Supplements Mk 1775,
955365-80-7 Yellow Solid
AZD1775 Sarms Anabolic Steroids Mk 1775 For Bodybuilding CAS 955365-80-7
Product Name: MK-1775
CAS No: 955365-80-7
Chemical Formula: C27H32N8O2
Exact Mass: 500.26482
Molecular Weight: 500.59538
Elemental Analysis: C, 64.78; H, 6.44; N, 22.38; O, 6.39
Soluble in 0.1N HCl(aq) and DMSO
Appearance: Yellow solid
Quality: As stated in COA/HPLC/MSDS report
Min order: 1Grams
Delivery: Within 3-5 days
Shipping: By Express TNT /DHL with tracking number provide
MK-1775 treatment led to the inhibition of Wee1 kinase and reduced inhibitory phosphorylation of its substrate Cdc2. MK-1775, when dosed with gemcitabine, abrogated the checkpoint arrest to promote mitotic entry and facilitated tumor cell death as compared to control and gemcitabine treated tumors. MK-1775 monotherapy did not induce tumor regressions. However, the combination of gemcitabine with MK-1775 produced robust anti-tumor activity and remarkably enhanced tumor regression response (4.01 fold) compared to gemcitabine treatment in p53-deficient tumors. Tumor re-growth curves plotted after the drug treatment period suggest that the effect of the combination therapy is longer-lasting than that of gemcitabine. None of the agents produced tumor regressions in p53-wild type xenografts.
MK-1775 inhibits Wee1 kinase in an ATP-competitive manner. Compared to Wee1, MK-1775 displays 2- to 3-fold less potency against Yes with IC50 of 14 nM, 10-fold less potency against seven other kinases with >80% inhibition at 1 μM, and >100-fold selectivity over human Myt 1, another kinase that inhibits cyclin-dependent kinase 1 (CDC2) by phosphorylation at an alternative site (Thr14).
By abrogating the DNA damage checkpoint via blockade of Wee1 activity in WiDr cells bearing mutated p53, MK-1775 treatment inhibits the basal phosphorylation of CDC2 at Tyr15 (CDC2Y15) with EC50 of 49 nM, and suppresses gemcitabine-, carboplatin- or cisplatin-induced phosphorylation of CDC2 and cell cycle arrest in a dose-dependent manner, with EC50 of 82 nM and 81 nM, 180 nM and 163 nM, as well as 159 nM and 160 nM, respectively. MK-1775 treatment alone at 30-100 nM has no significant antiproliferative effect in WiDr and H1299 cells, whereas MK-1775 at 300 nM, sufficient to inhibit Wee1 by >80%, displays moderate but significant antiproliferative effects by 34.1% in WiDr cells and 28.4% in H1299 cells.
We have professional team for package and shipment.Fast and secure shipment could be arranged for customs pass guaranteed.
Our company has independent import and export authority,also has the certificate of importing and exporting pharmaceutical materials. At the same time we are developed manufactures with mass stock.
Q1: Have your Product Quality been Approved by Third Party Lab ?
A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us.
Q2. Are you a manufacturer?
A: Yes, we have our own factory and lab.
Q3: Is there any discount?
A: Yes, as for old customers and larger quantity, we always support with great discounts and surprise.
Q4:Do you accept VISA business credit card ?
A:Sorry we don't accept VISA credit card, we'd like to accept Western Union, MoneyGram, Bank Transfer, Bitcoin, Litecoin.
Q5: How do you treat quality complaint?
A: First of all, our QC department will do strict examination of our export products in order to reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
Q6: How to proceed order?
1st: Please let me know what you need-Which product/Cas No. quantity, and the destination country.
2nd: You send us the purchase order once we come to an agreement on all details.
3rd: Parcel would be delivered upon full payment received.
4th: Express Tracking No.will be provided about the parcels.
5th: You will get the parcels within 7days.
6th: After-sales service would be provided after you receive parcels.
Payment & Shipping Terms:
|Minimum Order Quantity:||10g|
|Packaging Details:||Discreet Package|
|Delivery Time:||4-6 days to you|
|Payment Terms:||Western Union, MoneyGram, Bitocin, T/T|
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