Relieve Pain Anesthetic Powder Pramoxine Hydrochloride Hcl CAS 637-58-1

Relieve Pain Anesthesia Materials Pramoxine Hydrochloride Hcl CAS 637-58-1

Basic Information:

Product Name Pramoxine Hydrochloride
Synonym Pramoxine , Pramoxine HCL ,Proctofoam , Tronothane Hydrochloride
CAS 637-58-1
MF C17H28ClNO3
MW 329.86
EINECS 211-293-1
Assay 99%

Quality Standards Enterprise Standard/Pharma Grade
Appearance White powder
Package 25kg/Drum

Place of Origin China
Brand Name SMQ
Certification ISO9001, ISO14000, KOSHER
MOQ 1kg
Ref. Price USD 220/kg
Packaging Details 10kg/Drum, 1kg/bag
Delivery Time 1-2 days
Payment Terms T/T, Western union, Money gram
Supply Ability 5000 T/Month

Description:

Pramoxine Hydrochloride is the hydrochloride salt form of pramoxine, a morpholine derivative with local anesthetic property.Pramocaine hydrochloride decreases the permeability of the neuronal membrane to sodium ions by reversibly binding to and inhibiting voltage-gated sodium channels. This results in stabilization of the membrane and, thereby inhibiting the ionic fluxes required for membrane depolarization, hence resulting in the failure to initiate a propagated action potential and subsequent conduction blockade.
Pramoxine is used to temporarily relieve itching and pain caused by minor skin irritation such as minor burns/cuts/scrapes, sunburn, eczema, insect bites, cold sores, or rashes from poison ivy, poison oak, or poison sumac. Some products containing pramoxine are also used to temporarily relieve the itching and discomfort from hemorrhoids and certain other problems of the genital/anal area (such as anal fissures, itching around the vagina/rectum).

Pramoxine hcl,Pramocaine (INN and BAN, also known as pramoxine or pramoxine HCI) is a topical anesthetic discovered at Abbott Laboratories in 1953 and used as an antipruritic. Chemically, it is p-n butoxyphenyl gammamorpholinopropyl ether hydrochloride. During research and development, pramoxine hydrochloride stood out among a series of alkoxy aryl alkamine ethers as an especially good topical local anesthetic agent.
Pramoxine hcl,Pharmacologic study revealed it to be potent and of low acute and subacute toxicity, well tolerated by most mucous membranes and of a low sensitizing index in man. Like other local anesthetics, paramoxine decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses. Depolarization and repolarization of excitable neural membranes is thus inhibited, leading to numbness.

Application:

Topical anesthetics are used to relieve pain and itching caused by conditions such as sunburn or other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, and minor cuts and scratches. Pramocaine and dibucaine are also common ingredients in over the counter hemorrhoid preparations.

Anesthesia, local- Proparacaine and tetracaine are indicated to produce local anesthesia of short duration for ophthalmic procedures including measurement of intraocular pressure, removal of foreign bodies and sutures, and conjunctival and corneal scraping in diagnosis and gonioscopy. Proparacaine hydrochloride and tetracaine are also indicated to produce local anesthesia prior to surgical procedures such as cataract extraction and pterygium excision, usually as an adjunct to locally injected anesthetics. Ophthalmic solutions used for intraocular procedures should be preservative-free. Preservatives may cause damage to the corneal epithelium if a significant quantity of solutionenters the eye through the incision.

COA:

Fuction:

Structurally, it is the esther hydrochloride of p-n butoxyphenyl gammamorpholinopropane. The substance stood out as a good topical local anesthetic agent when Abbott Laboratories were researching a series of alkoxy aryl alkamine ethers for such an application. Pramocaine is tolerable by most mucus membranes and ranks low on the sensitizing index, making it unlikely to trigger an allergic reaction.

Surgical anesthesia:Epidural anesthesia (including epidural anesthesia during cesarean section);Local infiltration anesthesia.
Acute pain control:For postoperative or labor analgesia continuous epidural infusion can be used can also be intermittent medication;Local infiltration anesthesia.

Usages and Dosage:

Pramoxinehcl,Topical anesthetics are used to relieve pain and itching caused by conditions such as sunburn or other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, and minor cuts and scratches. Pramocaine and dibucaine are also common ingredients in over the counter hemorrhoid preparations.
Pramoxine hcl, Muscle relaxant (smooth)and slows growth of unwanted facial hair.

Pramoxine hydrochloride cream USP can be used by adults and adolescents as needed three to four times per day. The same dosing instructions can also be followed in the use of pramoxine hydrochloride lotion, pramoxine hydrochloride and menthol gel as well as pramoxine hydrochloride and menthol lotion. Proper dosing for pediatric use in children younger than two years old has not been established. Pramoxine should not be applied across large areas of the body and should not be used for extended periods of time as this may increase the risk of toxicity and systemic absorption.

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