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Pharma Antibiotic API Spironolacton For Diuretic Cas 52-01-7 USP Standard

Pharma Antibiotic API Spironolacton For Diuretic Cas 52-01-7 USP Standard

  • Pharma Antibiotic API Spironolacton For Diuretic Cas 52-01-7 USP Standard
  • Pharma Antibiotic API Spironolacton For Diuretic Cas 52-01-7 USP Standard
Pharma Antibiotic API Spironolacton For Diuretic Cas 52-01-7 USP Standard
Product Details:
Place of Origin: China
Brand Name: LiHui
Certification: Hplc ISO9001
Model Number: 52-01-7
Payment & Shipping Terms:
Minimum Order Quantity: 100g
Price: Negotiated
Packaging Details: Foil Bag
Delivery Time: 3-7days after received payment
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 5000Kg Per Month
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Detailed Product Description
CAS: 52-01-7 Color Or Appearance: White Crystalline Powder
Packing Specification: Aluminum Foil Bag Or Aluminum Tin 25 Kg/barrel Execution Standard: USP42
Product Purity: 99% The Product Level: Pharmaceutical Grade
Molecular Formula: C24H32O4S
High Light:

Pharma Antibiotic API

,

Antibiotic API Spironolacton

,

52-01-7 USP

Pharmaceutical Grade Raw Materials Powder Spironolacton For Diuretic Cas 52-01-7 USP Standard

 

 

Quick Detail:

Name: Spironolactone
CAS No.: 52-01-7
Formula: C24H32O4S
Molecular Weight: 416.62
Density: 1.24 g/cm3
Melting Point: 207-208 °C(lit.)
Boiling Point: 597 °C at 760 mmHg
Flash Point: 302.3 °C
Solubility: practically insoluble in water
Appearance: White to Off White Solid

Used as a diuretic, lactone (spironolactone), the active metabolite. Inhibition of aldosterone biosynthesis. Wow effect of blockers for Pakistan It is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia.

 

Description:

Spironolactone (INN, BAN, USAN) commonly referred to simply as spiro, and marketed primarily under the brand name Aldactone in most countries, is a synthetic, steroidal antimineralocorticoid and antiandrogen that also has some weak progestogen properties, as well as some indirect estrogen and glucocorticoid effects. It is used primarily as a diuretic and antihypertensive, but may also be employed for the purpose of reducing elevated or unwanted androgen activity in the body. It acts predominantly as an antagonist of the mineralocorticoid (or aldosterone) and androgen receptors, and in relation to its antimineralocorticoid effects, belongs to a class of pharmaceutical drugs known as potassium-sparing diuretics.
Spironolactone is a relatively old drug, having been introduced clinically in 1959. Futterman and Lemberg have predicted that spironolactone will be less commonly used in cardiovascular conditions (e.g., heart failure and hypertension) as the newer agents like the structurally-related compound eplerenone (also an aldosterone antagonist) are more selective and lack many of the side effects and actions of spironolactone that are undesirable in that particular patient population. However, spironolactone remains more widely used as an antiandrogen than eplerenone for patients in whom this effect is a main goal.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.

 

Application:

Spironolactone is used primarily to treat heart failure, edematous conditions such as nephrotic syndrome or ascites in patients with liver disease, essential hypertension, hypokalemia, secondary hyperaldosteronism (such as occurs with hepatic cirrhosis), and Conn's syndrome (primary hyperaldosteronism). On its own.
Because spironolactone reduces the body's production of testosterone and blocks the androgen receptors, it can cause effects associated with low testosterone levels and hypogonadism in males. For this reason, men are typically not prescribed spironolactone for any longer than a short period of time, e.g. for an acute exacerbation of heart failure. The newer drug, eplerenone has been approved by the U.S. Food and Drug Administration for treatment of heart failure, but lacks the rather potent antiandrogen effects and thus is far more suitable for men for whom long term medication is being chosen. Unlike with some other diuretics, potassium supplementation should not be administered while taking spironolactone as this may cause dangerous elevations in serum potassium levels resulting in hyperkalemia and potentially deadly cardiac arrythmias. Physicians must be careful to monitor potassium levels in both males and females who are taking spironolactone, especially during the first twelve months of use and whenever the dosage is increased.

Pharmaceutical Grade Raw Materials Powder Spironolacton For Diuretic Cas 52-01-7 USP Standard 0

 

COA:

 

Test Items Specification Test Results
Appearance Almost white crystalline powder Almost white crystalline powder
Identification Meet the requirements Meet the requirements
Melting range

198℃~209℃

Between 198℃ and 209℃

205.0℃~207.0℃
Specific rotation

-33°~-37°

Between -33° and -37°

-35°
Loss on drying

≤0.5%

Not more than 0.5%

0.2%
Limit of mercapto compounds Meet the requirements Meet the requirements
Ordinary impurities Meet the requirements Meet the requirements
Organic volatile impurities Meet the requirements Meet the requirements
Assay(on the dried basis)

97.0%~103.0%(C24H32O4S)

Between 97.0% and 103.0%

98.99%
Conclusion Meet the requirements of USP29

 

Our adwantage:

1, High quality with competitive price:

1) Standard: Enterprise Standard

2) All Purity≥98%

3) We are manufacturer and can provide high quality products with factory price.

 

2, Fast and safe delivery

1) Parcel can be sent out within 24 hours after payment. Tracking number available

2) Secure and discreet shipment. Various transportation methods for your choice.

3) Customs pass rate ≥99%

4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.

 

3, We have clients throughout the world.

1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.

2) Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.

3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.

Pharmaceutical Grade Raw Materials Powder Spironolacton For Diuretic Cas 52-01-7 USP Standard 1

 

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