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CAS 51352-87-5 Longan Powder PRL-8-53 Brain Improvement Supplements

CAS 51352-87-5 Longan Powder PRL-8-53 Brain Improvement Supplements

CAS 51352-87-5 Longan Powder PRL-8-53 Brain Improvement Supplements
CAS 51352-87-5 Longan Powder PRL-8-53 Brain Improvement Supplements
CAS 51352-87-5 Longan Powder PRL-8-53 Brain Improvement Supplements
Product Details:
Place of Origin: China
Brand Name: LiHui
Certification: Hplc ISO9001
Model Number: 51352-87-5
Payment & Shipping Terms:
Minimum Order Quantity: 10kg
Price: Negotiated
Packaging Details: Foil Bag
Delivery Time: 3-7days after received payment
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 5000Kg Per Month
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Detailed Product Description
CAS: 51352-87-5 Color Or Appearance: A Tablet Or Capsule
Packing Specification: Aluminum Foil Bag Or Aluminum Tin 25 Kg/barrel Execution Standard: USP42
Product Purity: 99% The Product Level: Pharmaceutical Grade
Molecular Formula: C18H22ClNO2 Product Use: Longan Powder
High Light:

51352-87-5 Longan Powder

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Longan Powder PRL-8-53

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PRL-8-53 Brain Improvement Supplements

CAS 51352-87-5 Nootropic Powder Smart Drug PRL-8-53 Improving Brain Cycle

 

PRL-8-53
Other Names:Methyl 3-[2-[benzyl(methyl)amino]ethyl]benzoate hydrochloride
Molecular Formula:C18H22ClNO2
Formula Weight:319.82578
CAS No.:51352-87-5
Appearance:white powder
Purity:99%

PRL-8-53 is a nootropic research compound first synthesized in the 1970’s by Dr Nikolaus Hansl while working at Creighton University. The compound takes its name from creator’s company Pacific Research Labs who were also the (now expired) patent holders. Very little research on this compound is available online. What is available appears to have been conducted by the old patent holder.

The single study involving humans showed PRL-8-53 improved word recollection scores both 24 and 96 hours after initial memorization. Given the low amount of evidence available for this nootropic, we thought it relevant to reference a journal article in which the creator discusses the compound and numerous other human trials it was used in.

Anecdotal reports for this seem favorable, though in the absence of reliable published research and data for prolonged use in humans, it’s not something we can recommend.

CAS 51352-87-5 Nootropic Powder Smart Drug PRL-8-53 Improving Brain Cycle 0

Abstract

 

PRL-8-53 (chemical name Methyl 3-(2-(benzyl(methyl)amino)ethyl)benzoate) is a synthetic nootropic compound discovered in 1972 and patented in 1975 by the late Dr. Nikolaus Hansl, a neuropharmacologist at Creighton University in Omaha, Nebraska. Preliminary animal tests indicated that the compound was both safe and significantly nootropic, boosting avoidance learning in rodents with no adverse effects. But the real interest in PRL-8-53 was sparked by a 1978 study on human volunteers, which showed that a single dose of the compound could improve word retention scores by more than 200%

 

Application

PRL-8-53's exact mechanisms of action are not well understood, but it is generally believed to regulate the brain's production of and response to several crucial neurotransmitters. In his reports on human and animal studies Hansl indicated that PRL-8-53 potentiates dopamine, partially restricts production of serotonin, and enhances the brain's response to acetylcholine.

Though Hansl's research report on the 1978 human study suggests those actions, it does not clearly delineate the mechanism of action.The fact that older subjects saw the most nootropic benefit from taking the drug supports the concept that dopamine modulation plays a major role in PLR-8-53's effects. Up-regulating the normal age-related lessening of dopamine production that is associated with cognitive decline could have a significant positive impact on both learning and memory.

 

Specification
Item Inspection Standard Results
Appearance Off white solid powder Conform
Identification Conform with NMR Conforms
Melting Point 149-152°C 150-151°C
Loss on Drying ≤0.50% 0.21%
Residue on ignition ≤1.0% 0.32%
Purity(HPLC) ≥99% 99.2%
Heavy metals NMT 20PPM Conforms
Conclusion:This product by inspection accords with the in-house standard
 

 

Dosage

The only human study on PRL-8-53 was based on the ingestion of a single 5 mg dose. There is no data on the effectiveness or potential toxicity of any other dosage in humans.

CAS 51352-87-5 Nootropic Powder Smart Drug PRL-8-53 Improving Brain Cycle 1

HOW Prl-8-53 HCl WORKS

PRL-8-53's exact mechanisms of action are not well understood, but it is generally believed to regulate the brain's production of and response to several crucial neurotransmitters. In his reports on human and animal studies Hansl indicated that PRL-8-53 potentiates dopamine, partially restricts production of serotonin, and enhances the brain's response to acetylcholine.


Though Hansl's research report on the 1978 human study suggests those actions, it does not clearly delineate the mechanism of action.The fact that older subjects saw the most nootropic benefit from taking the drug supports the concept that dopamine modulation plays a major role in PLR-8-53's effects. Up-regulating the normal age-related lessening of dopamine production that is associated with cognitive decline could have a significant positive impact on both learning and memory.

PRL-8-53 Dosage

The only human study on PRL-8-53 was based on the ingestion of a single 5 mg dose. There is no data on the effectiveness or potential toxicity of any other dosage in humans.

Prl-8-53 HCl SIDE EFFECTS

No adverse effects from a single 5 mg dose of PRL-8-53 were observed in the human study. Animal studies suggest that the compound has a high therapeutic threshold, but evidence is very limited because no comprehensive toxicity studies have been completed.

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