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797-63-7 Levonorgestrel Hormone Raw Material

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China Zhejiang Lihui Import Export Co., Ltd. certification
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797-63-7 Levonorgestrel Hormone Raw Material

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Large Image :  797-63-7 Levonorgestrel Hormone Raw Material

Product Details:

Place of Origin: China
Brand Name: LiHui
Certification: Hplc ISO9001
Model Number: 797-63-7

Payment & Shipping Terms:

Minimum Order Quantity: 10kg
Price: Negotiated
Packaging Details: Foil Bag
Delivery Time: 3-7days after received payment
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 5000Kg Per Month
Detailed Product Description
CAS: 797-63-7 Color Or Appearance: A Tablet Or Capsule
Packing Specification: Aluminum Foil Bag Or Aluminum Tin 25 Kg/barrel Execution Standard: USP42
Product Purity: 99% The Product Level: Pharmaceutical Grade
Molecular Formula: C21H28O2 Product Use: Women Use
High Light:

Levonorgestrel Hormone Raw Material

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797-63-7 Hormone Raw Material

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797-63-7 Levonorgestrel

CAS 797-63-7 Levonorgestrel Hormone Raw Material For Anti Early Pregnancy

 

 

Product Details:

 

Synonyms: 13-ethyl-17-alpha-ethynyl-17-beta-hydroxy-4-gonen-3-one;13-ethyl-17-alpha-ethynylgon-4-en-17-beta-ol-3-one;13-ethyl-17-hydroxy-19-dinor-17-alpha-pregn-4-en-20-yn-3-on(+)-1;17-alpha-ethinyl-13-beta-ethyl-17-beta-hydroxy-4-estren-3-one;17-beta-hydroxy-18-methyl-19-nor-17-alpha-pregn-4-en-20-yn-3-one;17-ethynyl-18-methyl-19-nortestosteron;17-ethynyl-18-methyl-19-nortestosterone;18-methyl-17-alpha-ethynyl-19-nortestosterone
CAS: 797-63-7

Assay: 99%
Formula: C21H28O2
Molecular Weight: 312.45
EINECS: 212-349-8
Density: 1.13 g/cm3
Melting Point: 206 ° C
Boiling Point: 459.1 ° C at 760 mmHg
Flash Point: 95.4 ° C
Appearance: White or almost white crystalline powder
Application: Progesterone medicine
Storage: Stored and protected from light

Usage: Progesterone drug, used for irregular menstruation, functional uterine bleeding, endometriosis

 

Description:


Levonorgestrel (or l-norgestrel or D-norgestrel) is a second generation progestin (synthetic progestogen) used as an active ingredient in some hormonal contraceptives, including combined oral contraceptive pills, progestogen only pills, emergency contraceptive pills, intrauterine systems, contraceptive implants, and hormone replacement therapy. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system
Levonorgestrel is used in emergency contraceptive pills(ECPs), both in a combined Yuzpe regimenwhich includes estrogen, and as a levonorgestrel-only method. The levonorgestrel-only method uses levonorgestrel 1.5mg (as a single dose or as two 0.75mg doses 12 hours apart) taken within 3 days of unprotected sex, with one study indicating that beginning as late as 120 hours (5 days) after intercourse could be effective. Levonorgestrel is a synthetic progestin that binds to progesterone and androgen receptors but not the estrogen receptor. Induces apoptosis in ovarian epithelium cells.

 

Application:

 

Oral contraception
At low doses, levonorgestrel is used in monophasic and triphasic formulations of combined oral contraceptive pills, with available monophasic doses ranging from 100-250 µ G, and triphasic doses of 50 µ G/75 µ G/125 µ G. At very low daily dose of 30 µ G, levonorgestrel is used in some progestogen only pill formulations.
Emergency contraception
Levonorgestrel is used in emergency contraceptive pills (ECPs), both in a combined Yuzpe regimen which includes estrogen, and as a levonorgestrel-only method. The levonorgestrel-only method uses levonorgestrel 1.5 mg (as a single dose or as two 0.75 mg doses 12 hours apart) taken within 3 days of unprotected sex, with one study indicating that beginning as late as 120 hours (5 days) after intercourse could be effective.
Intrauterine system
Levonorgestrel is the active ingredient in the Mirena & Skyla (Jaydess) intrauterine system.
Contraceptive implants
Levonorgestrel is the active ingredient in Norplant and Jadelle.
Hormone replacement therapy
Levenorgestrel is combined with 17-beta estradiol in the Climara Pro hormonal patch.

Applied in pharmaceutical field, Levonorgestrel can be used as an active ingredient in some hormonal contraceptives, including combined oral contraceptive pills, progestogen only pills, emergency contraceptive pills, intrauterine systems and contraceptive implants; Levonorgestrel is safe, tolerated and effective in emergency contraception in woman; Levonorgestrel also can be used for the treatment of menopausal and postmenopausal disorders and alone or in combination with other hormones as an oral contraceptive.

Oral contraceptives, levonorgestrel, also known as D- norethindrone, left Kanok ketone, is currently the most widely used oral contraceptives, the racemic optically active part of norethindrone, the activity ratio norethindrone strong double dose can be reduced by half, adverse reactions are also reduced accordingly. Rapid oral absorption, 0.5 ~ 1h, reached the peak. t1 / 2 of 10 ~ 24h.Protein binding rate of 93% to 95%, bioavailability, mainly located in the liver, kidney, ovarian and uterine body's organs and tissues, and its metabolites, mainly in the form of glucuronide and sulfate salts from the urine and feces in vitro. And ethinyl estradiol combination as a short-acting oral contraceptives. Its dual photo and three photo adverse reactions less, closer to women's normal hormone secretion type. Women can be used for emergency contraception, namely failure (condom slippage or breakage, coitus out of control, rhythm miscalculation, etc.) in the same room of post-coital contraception measures unprotected intercourse or other contraceptive methods.

 

COA:

 

Items
Specification

Results

Description

White or practically white crystalline powder

White crystalline powder

Specific Rotation

30°~-35°

32°

Melting Range

232~239°C, and melting range is not more then 4°C

234~238°C

identification

It complies with the test for specific optical rotation and melting point

Conforms
 
Infrared absorption spectrophotometry should be consistent with levonorgestrel CRS

Conforms

Loss on drying

≤0.5%

0.20%

Residue on ignition

≤0.3%

0.07%

Limit of Ethynyl Group

7.81%~8.18%

7.92%

Related substances

Single impurity ≤0.5%

single impurity<0.5%
 
Total Impurities ≤2.0%

Total impurities<2.0%

Organic Volatile impurties

Ethanol ≤5000ppm

1200ppm
Assay The product complies with specification in USP34

 

CAS 797 63 7 Levonorgestrel Hormone Raw Material For Anti Early Pregnancy 0

Levonorgestrel Medical uses


1. Birth control pills
At low doses, levonorgestrel is used in monophasic and triphasic formulations of combined oral contraceptive pills, with available monophasic doses ranging from 100-250 µg, and triphasic doses of 50 µg/75 µg/125 µg. At very low daily dose of 30 µg, levonorgestrel is used in some progestogen only pill formulations.

2. Emergency birth control
Levonorgestrel is used in emergency contraceptive pills (ECPs), both in a combined Yuzpe regimen which includes estrogen, and as a levonorgestrel-only method. The levonorgestrel-only method uses levonorgestrel 1.5 mg (as a single dose or as two 0.75 mg doses 12 hours apart) taken within 3 days of unprotected sex, with one study indicating that beginning as late as 120 hours (5 days) after intercourse could be effective.

The primary mechanism of action of levonorgestrel as a progestogen-only emergency contraceptive pill is, according to International Federation of Gynecology and Obstetrics (FIGO), to prevent fertilization by inhibition of ovulation and thickening of cervical mucus. FIGO has stated that: "review of the evidence suggests that LNG [levonorgestreol] ECPs cannot prevent implantation of a fertilized egg. Language on implantation should not be included in LNG ECP product labeling." In November 2013, the European Medicines Agency (EMA) approved a change to the label saying it cannot prevent implantation of a fertilized egg.

Other studies still find the evidence to be unclear. While it is unlikely that emergency contraception affects implantation it is impossible to completely exclude the possibility of post-fertilization effect. In November 2013, the EMA also approved a change to the label for HRA Pharma's NorLevo saying: "In clinical trials, contraceptive efficacy was reduced in women weighing 75 kg [165 pounds] or more, and levonorgestrel was not effective in women who weighed more than 80 kg [176 pounds]." In November 2013 and January 2014, the FDA and the EMA said they were reviewing whether increased weight and body mass index (BMI) reduce the efficacy of emergency contraceptives.

CAS 797 63 7 Levonorgestrel Hormone Raw Material For Anti Early Pregnancy 1

1. Why choose us

1. Rich experience

We specialize in this filed for many years,our steriods and hormones exported to all over the world and established long friendly relations of coroperation with them.

2. Great quality,purity and favorable

Good quality is one of our biggest secert to success;u can get the best quality and service from us.

3. Safest and fastest delivery

We have adequate stock so that we can deliver the products with 24 hours as soon as receiving the payment.Fast and discreet shipment will be arranged to pass customs.

4. Good package

Unique ways to ship 10g to 100kg powders to your destination.We offer melting powder into liquid service and ship the liquid in special bottles.

5. Great after-sales service

Any questions or problems after receiving the product,pls feel free to contact us.Problems would be solved immediately.

2. Order Guide

Q1: Have your Product Quality been Approved by Third Party Lab
A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us.

Q2: How do you treat quality complaint
A: First of all, our QC department will do strict examination of our export products by HPLC, UV, GC , TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.

Q3: Is there any discount
A: Yes, for larger quantity, we always support with better price.

Q4: How long does it take to the goods arrived
A:It is Depending on your location,
For small order, please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS.
For mass order, please allow 5-8 days by Air, 20-35 days by Sea.

Q5 Do you have any reshipment policy
A: We have good after-sale service and re-shipment policy if the parcel lose.
Our long association with our clients has brought great benefits.
We always take the upmost care in the packaging of our products .
our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts it is still possible will seize a small number of packages.
In this circumstance we promise reship free to establish long term relationship.

 

Estradiol Estrone
Estradiol valerate Estriol
Estradiol benzoate Nylestriol
Estradiol cypionate Diethylstilbestrol
Estradiol enantate HEXESTROL
Ethynyl estradiol Progesterone
Algestone acetophenide Medroxyprogesterone acetate
Ethisterone Norethindrone
19-Norethindrone acetate Mifepristone
Norethisterone Enanthate Methyldienedione
Ethynodiol diacetate Eplerenone
Pregnenolone acetate Levonorgestrel
Lynestrenol Allylestrenol
Chlormadinone acetate Dienogestrel
Cyproterone acetate Drospirenone
Megestrol acetate Pregnenolone
Melengestrol acetate Mometasone furoate
Betamethasone acetate Beclomethasone dipropionate
Betamethasone Dipropionate Betamethasone 17-valerate

Contact Details
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Contact Person: sales

Tel: +8613777515435

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