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Compound related drug description speech
Stanzol is a protein anabolic hormone with strong protein anabolic effect, 30 times of methyl testosterone, 1/4 of androgen activity and 120 differentiation index. It can promote protein synthesis, inhibit the dissimilar decomposition of histone, reduce blood cholesterol and triacylglycerin, promote calcium and phosphorus deposition and reduce bone marrow inhibition, etc. It can enhance physical strength, increase appetite and increase body weight, but the male effect is very weak.
Oral absorption from the gastrointestinal tract, plasma half-life of 4 to 5h, mainly excreted by urine.
Used in chronic wasting diseases, osteoporosis, serious diseases and weak emaciation after operation, old age, dysplasia in children, aplastic anemia, leukopenia, thrombocytopenia, hyperlipidemia, etc. Used for old and sick, postpartum weakness, etc. Also used for prevention and treatment of long-term use of corticosteroids caused by adrenal cortical hypofunction. 
Severe liver disease, kidney disease, heart disease, hypertension, pregnant women and prostate cancer patients are prohibited. 
Usage and dosage:
1. Commonly used by adults and adolescents
(1) Prevention and treatment of hereditary angoneeurotic edema: orally, 2mg (1 tablet) at the beginning, 3 times a day, 2mg (1 tablet) for women. Dosing should be individualized according to the patient's response. If the therapeutic effect is obvious, the dosage can be reduced every 1 to 3 months until 2mg (1 tablet) daily maintenance. However, in the process of reduction, the condition must be closely observed.
(2) For chronic wasting diseases, post-operation weakness, prolonged trauma treatment: oral, 3 times a day, 2-4mg (1-2 tablets), women moderate.
2. Normal dosage for children
It is used for hereditary angioneurotic edema. Under 6 years of age, 1mg (half tablet) daily orally, only during attacks; 6-12 years old, 2mg (1 tablet) daily orally, only during attacks. 
Matters needing attention
1. Patients suffering from gastric ulcer, liver, lung, heart and other dysfunction should be used with caution.
2. If use for a long time, can have liver dysfunction, icteric etc.
3. Discontinue medicine in case of acne and other masculine reactions. 
Medication for pregnant and lactating women:
Pregnant women are not allowed.
Medication for children:
Children with caution, precocious, affect growth.
Medication for the elderly:
Easy to cause water and sodium retention, hyperkalemia should be used with caution. 
1. Women: Long-term use may lead to acne, hairy, clitoral hypertrophy, amenorrhea or menstrual disorders.
2. Men: Long-term use may lead to acne, reduced sperm, reduced semen.
3. Liver: INCREASED GOP, GTP, jaundice.
4. Digestive system: nausea, vomiting, indigestion, diarrhea.
5. Electrolyte: water and sodium retention, edema.
6. Skin: rash, flushing. 
Interact with each other
The combination of adrenocorticosteroids, especially corticosteroids, increases the risk of edema. Adrenocorticotropic hormone or glucocorticoid combined with adrenocorticotropic hormone may accelerate the development of acne. The anticoagulant activity is enhanced by androgens and protein anabolic steroids, which reduce the concentration of clotting factor precursors (due to changes in the synthesis and decomposition of clotting factor precursors) and by increasing the affinity of anticoagulants to receptors. The dosage should be reduced when used with dicoumarin or indene diketone derivatives. When used in combination with hepatotoxic agents, liver damage may be exacerbated, especially in long-term use and in patients with pre-existing liver disease.
With barbiturates, carbamazepine, methylalanine, bute, rifamequine can reduce estrogen activity. 
Expert comments on speech
It was reported in China that 56 cases of aplastic anemia were treated with the combined regimen of sterazolol, anisodamine and polymethyletin (SAP regimen), the effective rate was 89%, and the effective rate was faster, and the cure and remission rate was higher (52%). Among 18 cases treated with stanzole alone, 4 cases were remission, 5 cases were obvious improvement and 9 cases were ineffective. The total effective rate was 50%. Stanzole can enhance hematopoietic stem cell proliferation and differentiation. SAP protocol was adopted to improve the curative effect of aplastic anemia by giving full play to the strengths of different drugs and supplementing their weaknesses. The assimilation of stanzool protein was 30 times that of met, and the androgen activity was 0.25 times that of meT. The differentiation index was 120, and there were few side effects of masculinization. The assimilation of stanzool protein was 30 times that of met, the androgen activity was 1/4 that of meT, and the differentiation index was 120. It has the functions of promoting protein synthesis, inhibiting protein heterogenesis, reducing blood cholesterol and triacylglycerin, promoting calcium and phosphorus deposition and reducing bone marrow inhibition, etc. It can enhance physical strength, increase appetite and increase weight, but it is masculine and has little adverse reaction. It is suitable for aplastic anemia, leukopenia, thrombocytopenia and so on. 
Clinical application of speech
Female patients using androgen or anabolic hormones, can cause male phenomenon, such as hairy, long beard, coarse voice and low tone, acne, generally in the withdrawal of symptoms can gradually subside. Male patients long-term use of these hormones, drugs may be transformed into estrogen in the body, and may inhibit the secretion of gonadotropin and cause testicular atrophy and inhibit spermatogenesis; Due to the inhibition of endogenous testosterone production, can lead to impotence; Long-term use of androgen in children can seriously affect growth and development, such as accelerated closure of epiphyseal can continue for several months after drug withdrawal; The application of anabolic hormones can lead to obesity.
The 17 alpha-methyl androgens have a serious effect on liver damage, mainly interfere with the excretory function of hepatic capillary bile duct, make bile stasis in the central capillary bile duct of liver lobule, resulting in cholestasis hepatocyte damage, clinical manifestations of cholestasis hepatitis. Long-term use of androgens may lead to liver cancer, prostate cancer and renal cell cancer. In addition, because of its water sodium retention effect, can cause edema. Use with caution in patients with kidney disease and heart failure, and contraindicate in pregnant women with prostate cancer.
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